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International Journal of Forensic Medicine

2022, Vol. 4, Issue 1, Part A

Autopsy, histopathology and nano technological study of the spleen in a case of aluminum phosphide poisoning in India


Author(s): Dr. Manoj Kumar and Dr. Nishant Purbey

Abstract: Introduction: Phosphine poisoning occurs infrequently. As of 1984, 94 cases had been reported in the world literature, with 28 deaths, but its frequency has increased recently. Cases of aluminum phosphide poisoning were first reported in India in 1980. Before then poisoning by aluminum phosphide in India was unknown. These poisoning are mostly suicidal.Material and Method: A 40 year old male resident of Phulwari Sharif, Patna, INDIA consumed 3 tablets of Aluminum phosphide. The patient was referred to AIIMS Patna higher center for treatment where he died at around 7:00 p.m. His body was kept overnight in AIIMS Mortuary cold chamber. An autopsy was performed at Mortuary of AIIMS Patna, INDIA. Chemical analysis report given by FSL, Patna came out positive for aluminum phosphide. All viscera sent for histopathology to Department of Pathology, AIIMS Patna, India. Spleen was sent for electron microscopic examination to CDRI, Lucknow, India.Result: The spleen was congested and edematous weighing 140 g; on histopathology, the spleen was markedly congested and showed focal areas of exudation and small hemorrhages with necrosis. Electron microscopy of a cut section of the spleen showed that the sinusoids were dilated and congested, and the splenic mucosa showed hemorrhagic infarction followed by necrosis.Conclusion: The histopathological report of the section of spleen showed hemorrhagic infarction, which is quite possible in Celphos poisoning, as it causes widespread organ damage with congestion and petechial hemorrhages, as well as edematous organs. Splenic necrosis is a sequela of infarction of the spleen. Sinusoidal dilatation of the spleen is due to its edema and the hypoxic damage002E.

DOI: 10.33545/27074447.2022.v4.i1a.40

Pages: 05-07 | Views: 92 | Downloads: 46

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How to cite this article:
Dr. Manoj Kumar, Dr. Nishant Purbey. Autopsy, histopathology and nano technological study of the spleen in a case of aluminum phosphide poisoning in India. Int J Forensic Med 2022;4(1):05-07. DOI: 10.33545/27074447.2022.v4.i1a.40
International Journal of Forensic Medicine