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International Journal of Forensic Medicine

2022, Vol. 4, Issue 2, Part A

Effect of extracts of dialium guineense stem bark on lipid peroxidation index and histological changes in kidneys of normal rats


Author(s): Abu OD, Ngedaa OS and Osarhenomase EG

Abstract: Aim: To investigate the effect of extracts of Dialium guineense stem bark on lipid peroxidation index and histological changes in kidneys of normal rats. Materials and Methods: Adult male Wistar rats (n = 70; 35 rats per extract) weighing 160 to 180 g were divided into seven (7) groups of five (5) rats each. Group I served as control, while rats in the other groups were administered varied doses of extract (200 - 5000 mg/kg body weight, bwt) orally for a duration of 28 days. Tissue malondialdehyde (MDA) level was measured as well as histopathological assessment. Results: Percentage increases in body weights of rats treated with aqueous or ethanol extract of D. guineense stem bark were significantly reduced, when compared with control group (p< 0.05), but there were no significant differences in the corresponding relative organ weights and tissue MDA level among the groups (p> 0.05). Similarly, the extracts did not significantly alter the normal architecture of the kidney. Conclusion: The aqueous and ethanol extracts of the medicinal plant did not elicit any deleterious effects on rat kidney.

DOI: 10.33545/27074447.2022.v4.i2a.52

Pages: 23-29 | Views: 25 | Downloads: 12

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How to cite this article:
Abu OD, Ngedaa OS, Osarhenomase EG. Effect of extracts of dialium guineense stem bark on lipid peroxidation index and histological changes in kidneys of normal rats. Int J Forensic Med 2022;4(2):23-29. DOI: 10.33545/27074447.2022.v4.i2a.52
International Journal of Forensic Medicine