Metabolic marker of acute cerebral circulation disorder in postmortal diagnosis
Author(s): Dr. Pavel A Akimov
Abstract: Postmortal biochemistry studies the patterns of development biochemical processes in the corpses, the correlation of lifetime and postmortal indicators, diagnostic criteria used to determine the causes of death. The aim of the research was to study the glucose and lactate content in cadaveric blood to develop a method for diagnosing acute cerebral circulatory disorders that does not depend on the duration of the post-mortem period. Biochemical blood analysis was carried out from 82 corpses, which were divided into 4 main groups (Mechanical asphyxia – suicide, mechanical asphyxia – murder, stroke, traumatic brain injury) and 2 comparison groups (Acute myocardial infarction and acute ethanol poisoning). To solve this problem, the glucose and lactate content were determined. The Delta-parameter was calculated, which is the difference in the total glucose and lactate content (in terms of glucose) between blood from the femoral vein and blood from the sinuses of the dura mater. In both comparison groups (Acute myocardial infarction and acute ethanol poisoning), the value of the Delta-parameter did not exceed 5.0 mmol/l. A significant (p =0.00000) increase in the Delta-parameter was found in all main groups with acute cerebrovascular accident – in persons who died as a result of stroke and traumatic brain injury and also in groups with mechanical asphyxia. A new metabolic marker of acute cerebrovascular accident is proposed - the Delta-parameter, which represents the difference in the total glucose and lactate content in terms of glucose between blood from the femoral vein and blood from the sinuses of the dura mater. The Delta-parameter exceeding 5.0 mmol/l indicates the onset of death as a result of acute cerebrovascular accident. At the same time, the reliability of the study (the value of the test) remains for a long post–mortem period – before the development of sharp putrefactive changes in the blood.
DOI: 10.33545/27074447.2023.v5.i2a.67Pages: 16-19 | Views: 204 | Downloads: 91Download Full Article: Click Here
How to cite this article:
Dr. Pavel A Akimov.
Metabolic marker of acute cerebral circulation disorder in postmortal diagnosis. Int J Forensic Med 2023;5(2):16-19. DOI:
10.33545/27074447.2023.v5.i2a.67
