Printed Journal   |   Refereed Journal   |   Peer Reviewed Journal

International Journal of Forensic Medicine

2024, Vol. 6, Issue 1, Part A

Assessment of sTWEAK protein, neutrophil-lymphocyte ratio, blood lactate and carboxyhemoglobin as predictors of delayed neurological sequelae after acute carbon monoxide poisoning


Author(s): Marwa Ahmed Mubarak, Doaa Mohamed El-Gharbawy, Ayman Abd El Fatah Wagih and Aisha Ibrahim Maklad

Abstract: Carbon monoxide (CO) poisoning exhibits a substantial importance as a toxicological reason for both morbidity as well as mortality worldwide. There is a strong demand for factors predicting sequelae (DNS) following acute CO intoxication. This study aimed to evaluate (sTWEAK) protein, (NLR), blood lactate level and carboxyhemoglobin (COHb) level as predictors for DNS following acute CO intoxication. Our prospective cohort study involved fifty individuals having acute CO intoxication who underwent Tanta University Poison Control Center’s admission in Egypt throughout a timeframe between the 1st of September 2020 till the conclusion of August 2021. While being admitted, all participants went through a comprehensive medical history, clinical findings, as well as routine laboratory testing. NLR was calculated, in addition to measuring sTWEAK, lactate, and COHb levels. Follow-up of these cases was done up to 40 days from acute exposure to CO to detect DNS manifestations. The results of this study reported elevation in all the studied markers (NLR, lactate, sTWEAK, and COHb). High significant associations were reported between DNS and both hyperlactatemia, elevated NLR, and high COHb level. ROC curve analysis for predicting DNS in acute CO intoxication exhibited, COHb level had the best area under the curve (AUC= 0.926) followed by NLR (AUC=0.903) then lactate (AUC=0.884). It could be concluded that; lactate, COHb and NLR were beneficial biomarkers to predict DNS among cases having acute CO intoxication, while sTWEAK level didn’t show a significant association with DNS.

DOI: 10.33545/27074447.2024.v6.i1a.68

Pages: 01-09 | Views: 387 | Downloads: 178

Download Full Article: Click Here
How to cite this article:
Marwa Ahmed Mubarak, Doaa Mohamed El-Gharbawy, Ayman Abd El Fatah Wagih, Aisha Ibrahim Maklad. Assessment of sTWEAK protein, neutrophil-lymphocyte ratio, blood lactate and carboxyhemoglobin as predictors of delayed neurological sequelae after acute carbon monoxide poisoning. Int J Forensic Med 2024;6(1):01-09. DOI: 10.33545/27074447.2024.v6.i1a.68
International Journal of Forensic Medicine

International Journal of Forensic Medicine

International Journal of Forensic Medicine
Call for book chapter